Huettner
Lab Publications
2021
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Strong KL, Epplin MP, Ogden KK, Burger PB, Kaiser TM, Wilding TJ, Kusumoto H, Camp CR, Shaulsky G, Bhattacharya S,
Perszyk RE, Menaldino DS, McDaniel MJ, Zhang J, Le P, Banke TG, Hansen KB, Huettner JE, Liotta DC, Traynelis SF. (2021)
Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors.
ACS Chemical Neuroscience, 12:79-98..
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Meganathan K, Prakasam R, Baldridge D, Gontarz P, Zhang B, Urano F, Bonni A, Maloney SE, Turner TN, Huettner JE, Constantino JN, Kroll KL. (2021)
Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7.
BMC Biology, 19:147..
2020
2019
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Chisari M, Wilding TJ, Brunwasser S, Krishnan K, Qian M, Benz A, Huettner JE, Covey DF, and Mennerick S (2019)
Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane
localization. Neuropharmacology, 144:91-103.
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Wilding TJ and Huettner JE (2019) Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix
bundle crossing. Journal of General Physiology, 151:435-451.
2018
2017
2016
2015
2014
2013
2011
2010
2009
- Webb
AB, Angelo N, Huettner JE, Herzog ED. (2009) Intrinsic,
nondeterministic circadian rhythm generation in identified mammalian
neurons. Proc
Natl Acad Sci USA,
106:16493-16498.
- Kim M, Habiba A, Doherty JM, Mills JC, Mercer RW, Huettner
JE. (2009) Regulation of mouse embryonic stem cell neural
differentiation by retinoic acid.
Developmental Biology, 328:456-471.
2008
- Laezza F, Wilding TJ, Sequeira
S, Craig AM, Huettner JE (2008) The BTB/kelch
protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate
receptors. Neuropharmacology, 55:
1131-1139.
- Wilding TJ,
Fulling E, Zhou Y, Huettner JE (2008) Amino acid substitutions in the
pore helix of GluR6 control inhibition by membrane fatty acids. Journal of General Physiology 32:
85-99.
2007
2006
- Huettner
JE, Lu A, Qu Y, Wu Y, Kim M, McDonald JW (2006) Gap Junctions and Connexon Hemichannels in
Human Embryonic Stem Cells. Stem
Cells. 24:1654-67.
- Drenan
RM, Doupnik CA, Jayaraman
M, Buchwalter AL, Kaltenbronn
KM, Huettner JE, Linder ME, Blumer KJ (2006) R7BP augments the
function of RGS7/Gbeta 5 complexes by a
plasma-membrane targeting mechanism. Journal
of Biological Chemistry e-pub Jul 25.
2005
- Drenan
RM, Doupnik CA, Boyle MP, Muglia LJ, Huettner
JE, Linder ME, Blumer KJ (2005) Palmitoylation
regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane
anchor for the RGS7 family. Journal
of Cell Biology 169:623-33.
- Leevy
WM, Gammon ST, Levchenko T, Daranciang
DD, Murillo O, Torchilin V, Piwnica-Worms
D, Huettner JE, and Gokel GW (2005)
Structure-activity relationships,
kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells. Organic and Biomolecular Chemistry
3:3544-3550.
2004
- Leevy
WM, Huettner JE, Pajewski R, Schlesinger PH,
Gokel GW (2004) Synthetic ion channel activity documented by
electrophysiological methods in living cells. Journal of the American Chemical Society 126:15747-53.
- McDonald
JW, Becker D, Huettner JE (2004) Spinal Cord Injury, in Handbook
of Stem Cells. Vol. 1, Lanza R, ed., Academic Press, NY.
2003
- Huettner
JE (2003) Kainate receptors and synaptic transmission. Progress in Neurobiology
70:387-407.
- Huettner JE.
(2003) Spine-tingling
excitement from glutamate receptors. Science
STKE. Nov 25;2003(210):pe53.
2002
2001
1999
- Gottlieb D.I. and Huettner J.E. (1999) An in vitro pathway from ES cells to neurons and Glia. Cells Tissues Organs, 165:165-172.
- Li
P, Kerchner GA, Sala C, Wei F, Huettner JE,
Sheng M, Zhuo M (1999) AMPA receptor-PDZ
interactions in facilitation of spinal sensory synapses. Nature Neuroscience 2:972-977.
- Li P, Wilding TJ, Kim SJ, Calejesan
AA, Huettner JE and Zhuo M. (1999) Kainate
receptor-mediated sensory synaptic transmission in mammalian spinal cord. Nature, 397:161-164.
1998
- Bain G., Yao M., Huettner J.E.,
Finley M.F.A., Gottlieb D.I. (1998) Neuron-like cells derived in culture
from P19 embryonal carcinoma and embryonic stem cells. In "Culturing
Nerve Cells, Second Edition" (Eds. Banker G and Goslin
K), MIT Press, Cambridge, pp. 189-211.
- Wilding T.J., Chai Y.-H. and Huettner J.E. (1998)
Inhibition of rat neuronal kainate receptors by cis-unsaturated fatty
acids. J. Physiol. 513:331-339.
- Huettner J.E., Stack E. and Wilding T.J. (1998)
Antagonism of Neuronal Kainate Receptors by Lanthanum and Gadolinium.
Neuropharmacology, 37:1239-1247.
- Segal M.M., Baughman R.W., Jones
K.A., Huettner J.E. (1998) Mass
cultures and microislands of neurons from
postnatal rat brain. In: "Culturing Nerve Cells, 2nd Edition"
(Eds. Banker G and Goslin K), MIT Press,
Cambridge, pp. 309-338.
1997
1996
- Canzoniero L.M.T., Sensi
S.L., Turetsky D.M., Finley M.F.A., Choi D.W.,
Huettner J.E. (1996) Glutamate receptor-mediated calcium entry in
neurons derived from P19 embryonal carcinoma cells.,
Journal of Neuroscience Research 45:226-236.
- Finley
M.F.A., Kulkarni N., Huettner J.E. (1996) Synapse formation and
establishment of neuronal polarity by P19 embryonic carcinoma cells and
embryonic stem cells. Journal of Neuroscience 16:1056-65.
- Guzikowski
A.P., Cai S.X., Espitia
S.A., Hawkinson J.E., Huettner J.E., Nogales
D.F., Tran M., Woodward R.M., Weber E., and Keana
J.F.W. (1996) Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione:
Structure-activity relationship at NMDA receptor glycine sites. J. Med.
Chem. 39:4643-4653.
- Wilding
T.J., Huettner J.E. (1996) Antagonist pharmacology of kainate- and
alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic
acid (AMPA)-preferring receptors. Molecular Pharmacology 49:540-546.
- Huettner J.E. (1996) Functional
properties of kainate receptors. In "The Ionotropic Glutamate
Receptors" (Eds. Monaghan DT and Wenthold
R) Humana Press, inc., Totowa, N.J.; pp.
265-283.
1995
- Bain G., Kitchens D., Yao M., Huettner J.E., and Gottlieb
D.I. (1995) Embryonic stem cells express neuronal properties in vitro.
Developmental Biology 168:342-357.
- Wilding
T.J., Huettner J.E. (1995) Differential antagonism of
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and
kainate-preferring receptors by 2,3-benzodiazepines.
Molecular Pharmacology 47:582-587.
- Woodward
R.M., Huettner J.E., Guastella J., Keana J.F.W., and Weber E. (1995) Pharmacology of
5-chloro-7- trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione:
a novel systemically active ionotropic glutamate receptor antagonist.
Journal of Pharmacology and Experamental
Therapeutics 275:1209-18.
1994
1993
1992
1991
- Baughman R.W., Huettner J.E.,
Jones K.A. and Khan A.A. (1991) Cell culture of neocortex and basal
forebrain from postnatal rats. In: "Culturing Nerve Cells" (Eds.
Banker G and Goslin K), MIT Press, Cambridge,
pp. 227-249.
- Huettner J.E. (1991) Competitive
antagonism of glycine at the NMDA receptor. Biochemical Pharmacology
40:9-16.
1990
- Huettner
J.E. (1990) Glutamate receptor channels in rat DRG neurons: Activation
by kainate and quisqualate, and blockade of
desensitization by Con A. Neuron 5:255-266.
- Huettner J.E. (1990) Antagonists
of NMDA-activated current in cortical neurons: competition with glycine
and blockade of open channels. In: "Excitatory Amino Acids and
Neuronal Plasticity" (Ed. Ben-Ari Y), Plenum, New York, pp. 35-43.
1989
- Huettner
J.E. (1989) Indole-2-carboxylic acid: A competitive antagonist of
potentiation by glycine at the NMDA receptor. Science 243:1611-1613.
1988
- Huettner
J.E. and Bean B.P. (1988) Block of N-methyl-D-aspartate-activated
current by the anticonvulsant MK-801: Selective binding to open channels. PNAS, USA
85:1307-1311.
- Huettner
J.E. and Baughman R.W. (1988) The
pharmacology of synapses formed by identified corticocollicular
neurons in primary cultures of rat visual cortex. Journal of Neuroscience
8:160-175.
1986